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Lecture 6

Kinesiology 2230A/B Lecture Notes - Lecture 6: Thiolase, Acetyl-Coa, Glycolysis


Department
Kinesiology
Course Code
Kinesiology 2230A/B
Professor
Glen Belfry
Lecture
6

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January 15, 16
2230 Lecture 6
Aerobic and anaerobic performances
2015 world cycling championships
261 km – avg 42 km/h
1648 m or 5000 ft. of climbing
UC Hill is about 50ft (100 x’s)
6 hours 14 minutes (fats)
Bradley Wiggens
Distance in one hour
54.5 kms
Fat Metabolism (aerobic)
Triglyceride
H  ETC
Breaking down fats for energy is ONLY aerobic
There are 3 fatty acids
Fat Mobilization from Adipose Tissue
Stimulus: Catecholamine’s – epinephrine and nor epinephrine
From the adrenal glands on the kidneys
Triglyceride gets broken down into diglyceride by rate limiting
enzyme
Split o7 another fatty acid by same enzyme to glycerol with 1
fatty acids bound to it
Splitting last fatty acid from glycerol, 2 enzymes required to a
monoglyceride + FA
Released into blood stream, in blood going up during exercise
Does not begin to happen until 15 minutes of exercise
Anything before 15 minutes, not burning much fats, just CHO

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Fatty Acid Transfer to Mitochondria (picture below)
Needs to be transported by the blood stream to the working
muscle
FA bound to plasma protein Albumin
Arrives at working muscle, then FA needs to be bound to
sarcolemma
- Has to make it into the mitochondria because that where the
aerobic metabolism occurs
FA + ATP + CoA is required in presence of acyl- CoA synthase to
give us the fatty acyl-CoA. This will move through outer
mitochondrial membrane
IF RESTING SITUATION: the acyl-CoA can be stored in the muscle
as triglyceride
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