Microbiology and Immunology 2500A/B Lecture Notes - Lecture 99: Measles, Acute-Phase Protein, Apoptosis
15 Feb 2017
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Document Summary
Innate immunity is shared but adaptive is unique. Innate responds the same way every time but adaptive remembers and diff responses between first and subsequent exposure. Modes: ingest contaminated food and into gastrointestinal tract, open wound (skin, respiratory tract, reproductive tract. Epithelial cells line skin and tracts important in blocking pathogens: has no gaps. Coughing, sneezing, vomiting, diarrhea, urine, tears, salvia , mucus, blink, cilia. Highest number of fluora in mouth airborne or ingesting pathogens fast flow rate. Lower intestinal tract low flow rate so allows normal fluora to establish and replicate. Microbiota affects development of immune and how well it functions. Flora gets into tissue can replicate and become a pathogen (allow it to sit it can colonize) Double dose antibiotics can kill normal flora bacteria then gaps forms in epithelial cells leads to bacterial infection in tissue. Certain pathogens evolved can directly invade the epithelial cell barrier. If epithelial cell barrier is permeated innate cells are activated.
