KP222 Lecture Notes - Lecture 6: Nicotinic Acetylcholine Receptor, Neuromuscular Junction, Axon Terminal
Lecture 6:
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Action of NT can be long or short or excitory or inhibitory
Depends on the NT and the receptor it binds to
Fast Response
Iontropic receptor – ligand channel
Both have to be positive charged
If at rest, it will be sodium that moves the fast, wants to be +60
- Big driving force for sodium, more sodium in then potassium out
- If the cell was at +30: open the channel at 30, the potassium would mive more
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Document Summary
Action of nt can be long or short or excitory or inhibitory. Depends on the nt and the receptor it binds to. If at rest, it will be sodium that moves the fast, wants to be +60. Big driving force for sodium, more sodium in then potassium out. If the cell was at +30: open the channel at 30, the potassium would mive more. Preventing potassium movement (leaving cell) causes excitatory post synaptic potential. Ligand binds open, channels previously closed = hyperpolarization. Move freely back and forth the membrane. Nothing is going to happen, already at equilibrium. When nt opens up the channel, moving in, excitatory response. Moving of positive charge now creates a electrochemical driving force. If wanted to fire, not active chloride channel. Firing quickly enough in time for the epsp to add up. Have to be close together in time.
