PS268 Lecture Notes - Lecture 9: Chemotherapy, Spasticity, Cannabidiol
Document Summary
Hashish concentrated resin from the cannabis plant. Ganja (sinsemilla) dried flowering tops of plants with pistillate flowers (females), without seeds, high grade or more potent marijuana. Morocco largest supplier of hash to world market, also afghanistan and pakistan. Compassion clubs work outside canadian laws, buying at clubs is illegal. If smoked peak effects occur within 5-10 minutes and within 30 minutes much is gone from the brain. If eaten peak effect occurs around 90 minutes. Thc in blood has half-life of 19 hours, thc in liver has half-life of 50 hours. Can take two to three weeks for all thc and metabolites to leave body, still 25-30% left after one week. Anandamide a chemical isolated from brain tissue that has marijuana like properties. Cb2 receptors found mainly outside the brain in immune cells. Increased heart rate, more with higher dose: oral peak at 90 mins last another 4 hours, smoked peak at 10 mins return to baseline after 90 minutes.
