ADMS 3502 Lecture Notes - Lecture 6: Pregnane X Receptor, Lipodystrophy, Prednisone
21 May 2020
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Nuclear receptors are composed of several distinct protein domains. For simplicity, the domains are often labeled with the letters a through f. below is a 2- dimensional structure of a typical nuclear receptor. For each section (a f), provide the name of the domain and the main role with respect to nuclear receptor activity or function. A/b = n-terminal domain contains af1 (involved in transcription activation) C = dna binding domain binds to specific hre. D = hinge region contains nuclear localization signal unmasked by hsp. E = ligand binding domain dimerization and cofactor interaction (af2) In simple terms and with the help of a diagram, describe the structure and function of a zinc finger. ". Zinc fingers are part of the dbd of a nr. They contain 8 cysteines which coordinate 2 zinc atoms. They contain a p-box (p=proximal) which dictates binding-motif specificity through hexanucleotide half-sites which interface perpendicularly to dna.
