ADMS 3502 Lecture Notes - Lecture 26: Nephron, Renal Physiology, Cisplatin

• School: York University
• Department: Administrative Studies
• Course: ADMS 3502
• Professor: Cristobal Sanchez- Rodriguez

Document Summary

Incidence and prevalence: patients in hospital are already debilitated, can be dehydrated. Contrast media agents: iodine compounds, these are tri-iodated benzoic acid derivatives that are used for diagnosis of some of the renal disorders like obstruction. Antibiotics such as aminoglycosides as well as some anti-cancer drugs like cisplatinum with a heavy metal nsaids like indomethasin used over the counter at large by population. Mechanisms involved in drug nephrotoxicity 2 types: non immune mediated and immune mediated. E) dehydration: if patients that are dehydrated can have loss of water fluids then further concentrations of solutes and toxins at kidney that can"t be flushed out so enhancing risk of toxicity. F) changes in urine ph, if precipitation then we can have some obstruction, concerned about sulfa derivatives which are commonly used antimicrobial agents and one important advice when give sulfa is advise patient to drink lots of water. G) these are ca+2 blockers these can enhance propensity to drug toxicity.