BIOL 2021 Lecture Notes - Lecture 19: Cytochrome C, Fas Ligand, Membrane Potential
30 Mar 2017
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Fig 17-11: control of division and growth, mitogen cell division, g1/s cdk phosphorylate and inactivate apc/c cdh 1, s-cyclin accumulation --?s cdk s phase. Fig 17-16 checkpoints: dna damage checkpoint, late g (start) and g2/m, detects dna damage. Next: dna damage repaired checkpoint is lifted. Question: one important biological effect of a large dose of ionizing radiation is to stop cell division. Why: a: radiation leads to dna damage, which activates atm and atr kinases and the dna damage checkpoint. Question: an adult human will die within a few days of receiving a large dose of ionizing radiation. Why: a: cell division does not stop when we reach maturity. Blood cells, epithelial cells in these kin or lining of the gut and the/ missing! Unicell: nutrients control growth and division. Multicell: need a growth factor = extracellular signal, bind to receptor, stimulates the synthesis of proteins and other macromolecules.
