BIOL 2021 Lecture 2: covlently attached lipids
19 Jan 2018
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Document Summary
Covalently attached lipid: fatty acids can link the protein to the membrane (5: amide linkage between terminal amino group. Some proteins are attached to the lipid bilayer only by a covalent linkage (via a specific oligosaccharide) to a lipid anchor in the outer monolayer of the membrane (6: usually involved in signaling. Covalent attachment to glycosyl phosphatidylinoditol/gpi anchor: inositol lipid and sugars which are covalently attached to the membrane in the er (6) Peripheral/membrane-associated proteins: don"t extend into the hydrophobic interior of the lipid bilayer at all and are instead non-covalently bound to membrane proteins (7, 8: associate with just one side of the membrane. Proteins are never found fully buried in the lipid bilayer. The tips of proteins are theoretically never found buried in the bilayer. Transmembrane: functions on both sides of the membrane: transport, cell-surface receptors transferring cell signals. Attached on cytosol side: signals relay from transmembrane proteins to cytosolic proteins, ex. protein kinases.
