CHEM 3050 Lecture Notes - Lecture 21: Citric Acid Cycle, Alpha-Ketoglutaric Acid, Pyruvic Acid
2 May 2018
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CHEM 3050
Lecture 21
Energetics of the Citric Acid Cycle
- Low retention time of any of the intermediates with a
near zero ∆G
- The front end is so exergonic (highly negative ∆G),
you’re driving it to come back by near neutral
reactions as the cycle goes around
o The massive differences come from the real
world environment of the cell; the reactions
happening together in non-standard conditions
this is good for us
Regulation of the Citric Acid Cycle
- Calcium levels turn up the conversion of pyruvate to
acetyl-CoA
o Low energy turns it up
- High NADH feedback inhibits the conversion to
acetyl-CoA, citrate formation, α-ketoglutarate
formation and succinyl-CoA formation
- The front half of the cycle is highly regulated
highly exergonic
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