CHEM 3050 Lecture 16: CHEM 3050 Lecture 16
2 May 2018
School
Department
Course
Professor
CHEM 3050
Lecture 16
- Depending on whether we’re doing anaerobic or
aerobic work we can oxidize NADH NAD+ back to
NAD to reduce pyruvate to lactate or ethanol; the
fermentation to lactate happens in vigorously
contracting muscle, in erythrocytes and in some
other cells; microorgansims use anaerobic processes
like this. A.k.a fermentation of ethanol to yeast
- Pyruvate is converted to lactate by oxidation of
NADH to NAD+ by lactate dehydrogenase, which is
under zymogen control! not active until it needs
to be used
o NADH does a hydride shift by adding a hydride
- Pyruvate is converted to acetaldehyde by pyruvate
decarboxylase, which kicks out a carbon dioxide;
resulting acetaldehyde is reduced in a hydride
shift/attack stabilized by magnesium and other
structures that stabilize the appropriate oxyanions
- All of these reactions occur in the cell spontaneously
because their Free energy change is much more
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Depending on whether we"re doing anaerobic or aerobic work we can oxidize nadh nad+ back to. Nad to reduce pyruvate to lactate or ethanol; the fermentation to lactate happens in vigorously contracting muscle, in erythrocytes and in some other cells; microorgansims use anaerobic processes like this. Pyruvate is converted to lactate by oxidation of. Nadh to nad+ by lactate dehydrogenase, which is under zymogen control! Not active until it needs to be used: nadh does a hydride shift by adding a hydride. Pyruvate is converted to acetaldehyde by pyruvate decarboxylase, which kicks out a carbon dioxide; resulting acetaldehyde is reduced in a hydride shift/attack stabilized by magnesium and other structures that stabilize the appropriate oxyanions. Store glucose by making glucose from pyruvate or use it for other purposes. Its an alternative step to the end of glycolysis that bypasses certain steps in glycolysis. It occurs in the mitochondria to form phophoenolpyruvate (pep), which then needs to be transported out.
