KINE 1000 Lecture Notes - Lecture 11: Filopodia, Plectin, Intermediate Filament
4 Jun 2018
School
Department
Course
Professor
Liker Proteis Coect Cytoskeletal
Filaets & Bridge Nuclear Evelope –
Plecti
• Intermediate filament network is linked to rest of cytoskeleton by proteins called
plakins
• Plakins contain multiple domains that connects cytoskeletal filaments to each
other & to junctional complexes
• Plectin links intermediate filaments to microtubules, actin filaments and
filaments of motor protein myosin. Plectin helps attach intermediate filament to
structures at plasma membrane
• Plectin & other plankins interact with protein complexes that connect
cytoskeleton to nuclear interior
• Mutations in gene for plectin causes human diseases like abnormal skin and heart
muscles
• Cross-linking is actin required to provide cells with strength they need to
withstrand mechanical stresses
• Figure shows plectin (green) connecting intermediate filaments (blue) to
microtubules (red)
Cell Polarization & Migrations
• How are cells polarized & how do they define front vs back. How do they crawl?
• Cell migration relies on coordinated deployment of components & processes of
dynamic assembly and disassembly of cytoskeletal polymers, regulation &
modification of their structure by polymer associate proteins & actions of motor
proteins moving along the polymers or exerting tension against them
• Cell migration depends on actin-rich cortex beneath plasma membrane. Activities
occurs simultaneously & cell seems to glide fwd smoothly w/o changes in shape.
find more resources at oneclass.com
find more resources at oneclass.com
