KINE 3012 Lecture Notes - Lecture 1: Carbonic Anhydrase, Carbamino, Pressure Gradient

• School: York University
• Department: Kinesiology & Health Science
• Course: KINE 3012
• Professor: Michael Connor

Document Summary

January 26th lecture note: we want to keep oxygen in blood high. Co2 transport in blood: high in tissue & low in air & alveoli, three difference pressures for co2, venous- 46mmhg, alveolus 40mmhg, arterial 40mmhg. Co2 is transported in multiple ways: 10% dissolved in plasma, 30% bound to hb (hbco2; carbamino hb) Binds to amino side chain of globin molecule: 60% converted to bicarbonate (hco3-) Intermediate is carbonic acid: carbonic anhydrase is enzyme needed to convert co2 & water to carbonic acid. Rbc: carbonic acids dissociate spontaneous into bicarbonate (no pressure, co2 gets converted to bicarbonate & h+ ------ equilibrium, driven by co2 gradients b/t blood & tissue. Increasing co2 results in increase in bicarbonate & hydrogen. Co2 binds to hb (hb affinity for co2 > O2: formation of bicarbonate allows us to keep pressure of co2 in rbc low, bicarbonate carries negative charge; the cell becomes more positive. Concentration of bicarbonate and charges must be balanced.