MELS223 Lecture Notes - Lecture 14: Gram-Positive Bacteria, Neutrophil, Upper Respiratory Tract Infection

• School: University of Otago
• Department: Medical Laboratory Science
• Course: MELS223
• Professor: Jenny Rhodes

Document Summary

Shia or shiga-like toxins kill host cells by blocking protein synthesis. High local concentration of toxin is needed to damage cells. 3 different types of toxins: surface acting toxins. Binds to receptor on plasma membrane and causes damage to human cell. Puts holes in phagosome to help bacteria escape (listerilysin). Others also put holes in membrane plasma membrane. Listeriolysin o: a/b toxins have 2 components, a domain and b domain. Linked together in same protein and separated later on or actually separate toxins. B subunit function is to bind to surface and help deliver a into cell. Diptheria toxin- exits from endosome and affects protein synthesis. Gram positive cocci, colonize skin and anterior nares. Disease: skin infections, medical implant associated infections, invasive disease (endocarditis), necrotizing fasciitis in blood stream. 20% of genes vary in different strains of same species of staph aureus.