The following are potential therapeutic approaches for controlling cholesterol
STATIN- It particularly well suited for lowering LDL(bad cholesterol) , this cholesterol with the strongest links to vascular diseases.
Fibrate- Indicated for hypertriglyceridemia. Fibrates typically lower triglycerides by 20% to 50%. Good cholesterol HDL is also increased. Fibrates may decrease LDL, though generally to a lesser degree than statins.
Niacin-Like fibrates, is also well suited for lowering triglycerides by 20â50%.
Bile acid sequestrants-Resin e.g cholestyramine are particularly effective for lowering LDL-C by sequestering the cholesterol-containing bile acids released into the intestine and preventing their reabsorption from the intestine.
Ezetimibe-It is a selective inhibitor of dietary cholesterol absorption.
Phytosterols- It may be found naturally in plants. It also reduce the absorption of cholesterol in the gut. Hence, they are most effective when consumed with meals.
Orlistate -Its primary function is to prevent the absorption of about 30% of fats from the human diet, thereby reducing caloric intake.
Explain whether each approach listed above would be of potential benefit to an individual:
Who produces defective LDL receptors-
Who has very high HMGCoA reductase activity-
Whose chylomicron remnant uptake mechanisms are defective-