BIO-1801 Lecture Notes - Lecture 9: Pyruvate Dehydrogenase, Acetyl-Coa, Oxidative Phosphorylation

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14 May 2018
School
Department
Course
Cellular
Respiration
Glycolysis:
-Glucose (6C) is broken down into two pyruvate (3C)
-Occurs in cytosol of eukaryotes and prokaryotes.
- Glucose is oxidized, Oxygen is reduced.
-2 ATP goes in, 2NADH & 4 ATP are produced (Net gain:
(2ATP))
-Exergonic as a whole b/c net gain of ATP, releasing energy.
(Reduction)
-Regulated by feedback inhibition (allosteric): High levels of
ATP inhibit the third enzyme (phosphofructokinase) which has
two binding sites for ATP.
Substrate level phosphorylation: is a metabolic reaction that
results in the formation of ATP by the direct transfer of a
phosphoryl (PO3) group to ADP from
another phosphorylated compound. (Involves an Enzyme &
Phosphorylated Substrate)
Chemiosmosis is the movement of ions across a
semipermeable membrane, down their electrochemical
gradient. An example of this would be the generation of
adenosine triphosphate (ATP) by the movement of hydrogen
ions across a membrane during cellular respiration or
photosynthesis.
Energy investment phase: (reactions 1-5) First uses 2 ATP
Energy Payoff Phase: (reactions 6-10) Produces 4 ATP (substrate level phosphorylation) and
2 NADH
Pyruvate Processing:
-Pyruvate (3C) is oxidized to form acetyl CoA (2C) + CO2
- Occurs in Mitochondrial Matrix (cytosol for prokaryotes)
-Uses enormous enzyme complex called pyruvate
dehydrogenase
- what goes in: 2 pyruvate oxidized into acetyl CoA -
2x per glucose
-what comes out: 2NADH & 2 acetyl CoA (acetyls attached to
coenzyme A)
- Regulated by feedback inhibition (Inhibitory allosteric
phosphorylation of pyruvate dehydrogenase occurs when
products of glycolysis and pyruvate processing are high)
NAD+
Coenzyme A
(CoA-SH)
NADH
Pyruvate
Acetyl CoA
C6H12O6 + 6 O2 6 CO2 + H2O
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Document Summary

C6h12o6 + 6 o2 6 co2 + h2o. Glucose (6c) is broken down into two pyruvate (3c) 2 atp goes in, 2nadh & 4 atp are produced (net gain: (2atp)) Exergonic as a whole b/c net gain of atp, releasing energy. (reduction) Regulated by feedback inhibition (allosteric): high levels of. Atp inhibit the third enzyme (phosphofructokinase) which has two binding sites for atp. Substrate level phosphorylation: is a metabolic reaction that results in the formation of atp by the direct transfer of a phosphoryl (po3) group to adp from another phosphorylated compound. (involves an enzyme & Chemiosmosis is the movement of ions across a semipermeable membrane, down their electrochemical gradient. An example of this would be the generation of adenosine triphosphate (atp) by the movement of hydrogen ions across a membrane during cellular respiration or photosynthesis. Pyruvate (3c) is oxidized to form acetyl coa (2c) + co2. Occurs in mitochondrial matrix (cytosol for prokaryotes)

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