PSYC 340 Lecture Notes - Lecture 28: Chronic Traumatic Encephalopathy, Single-Photon Emission Computed Tomography, Major Trauma
21 Oct 2020
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Document Summary
Chronic traumatic encephalopathy (cte): atrophy of the brain, typically in response toa history of physical trauma to the head. Monozygotic twins have much higher concordance for suicidality than dizygotic twins. Cluster b personality traits and impulsive-aggressive behaviour represent intermediate phenotypes of suicide that partially mediate the relation between familiar predisposition and suicide attempts among relatives. Low levels of serotonins major metabolite, 5-hiaa, found in people in categoriesof depression, schizo, and personality disorders - who committed suicide. Post mortems show increased binding by serotonin receptors (responses to decreased serotonin) The link between 5-hiaa levels and suicide is compelling int he case of violent and impulsive suicide. No signi cant differences between suicide attempters and control subjects with respect to regional levels of serotonin reuptake (5htt) and dopamine reuptake binding potential. In suicide attempters but not controls they found signi cant regional correlations between levels of measures of impulsiveness/initiative and mental energy and spect results.
