BIO 282 Lecture Notes - Lecture 5: Conformational Change, Phosphodiesterase, Cholera
Document Summary
Epinephrine (epi), a small amine hormone binds to and activates epi receptors on the heart causing a faster heart rate and increase heart contraction force. Antagonist block so the receptor does not get activated. Key point: receptor antagonists bind to receptors, but do not activate them and/or do not induce a conformational change. Receptor agonists bind to receptors and activate them. Lots of different effects and responses for different functions or parts of the body. Key point: a given receptor is designed to bind specifically to one signaling molecule. Type of receptor may exist on many different types of tissues, resulting in many tissues responding to the same signal. But those tissues can response in different ways. Why do you suppose that is: provides greater specificity in signaling. Key point: sometimes there may be more than one type of receptor for a given hormone. Know if receptor is inhibitory and stimulatory. You should know what inhibitory and stimulatory g-proteins do.
