PSYC BC 1119y Lecture Notes - Lecture 7: Morphine, Antipsychotic, Endorphins
4 Nov 2015
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Symptoms: loss of speed in cns->numbness, trouble w/ balance, changes in cognitive function. Symptoms within an individual can fluctuate- some flare ups and some remissions. Usually diagnosed in ppl 25-50 yrs of age. 2/3 times more common in women than men. Ms cases appear to be increasing, but likely b/c of better diagnosis and awareness of the disease. Immune modifiers: antineoplastics (i. e. novantrone) suppress aspects of the immune system. Stimulate myelin production: increase the myelin present or induce some new myelin to form (oligodendrocytes) Synthesis: choline+acetyl coenzyme a + [choline acetyltransferase (chat)] acetylcholine. Metabolism: acetylcholine + [acetylcholinesterase (ache)] acetylcholine breakdown: monoamines. Catecholamines (dopamine da, norepinephrine ne, and epinephrine e) Synthesis: tyrosine + [tyrosine hydroxylase] dihydroxyphenylalanine (dopa) + [dopa decarboxylase] da. Metabolism: da, ne, or e + [monoamine oxidase] da, ne, or e breakdown. Synthesis: tryptophan + [tryptophan hydroxylase] 5-hydroxytryptophan + [aaac] 5-ht. Metabolism: 5-ht + [monoamine oxidase] 5-ht breakdown: amino acids. Excitatory amino acids (glutamate and aspartate)- lead to epsps.
