BIO 3422 Lecture Notes - Lecture 8: Afferent Arterioles, Renal Corpuscle, Distal Convoluted Tubule

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16 Dec 2017
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Renal cortex: glomerulus + bowman"s capsule = renal corpuscle (where filtration occurs) Vascular: afferent arteriole (carry blood to capillaries) glomerulus/glomerular capillaries efferent arterioles (carry blood away from capillaries) peritubular capillaries (surround tubules) to return to venous system, portal system: 2 capillary beds in series. Tubular: bowman"s capsule/space proximal tubule loop of henle descending. Ascending (thick) distal tubule collecting duct. Filtration: moving out of capillaries into interstitial/bowman"s space. Filtration membrane highly fenestrated: prevent large molecules (rbc, proteins), allow water, ions. Capillaries porous: filtration allow movement through pores basal membrane podocytes bowman"s space. Net filtration pressure nfp = (pgc + bs) ( gc + pbs) pressure proportional to how much fluid filtered or urine output. Forces favoring filtration (movement into bowman"s space/tubular lumen) Glomerular capillary hydrostatic pressure: remains constantly high, most significant factor to nfp, amount of filtrate formed and urine produced is primarily regulated by adjusting pgc (varying degree of resistance)

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