CHEM 3A Lecture Notes - Lecture 8: Apnea, National Institutes Of Health
1
KEYG TO NUUEOPHKEG :e
.
2
4
*
tend is opposite L#'S @
-u
&
Basicity
:Decreases to Matt =Nw
HZN :>Hid ;Hunt >HE:
'
>¥.
:*
Nonbasihity
:macaws Down PT =Nu LDiffers from bases )
-Due to solvent Effects &polavizabiwty (deformability of orbital CNND )
&r
solvent Effects :
-
charged Nui :mainly sowation by pwtiv &highly polar solvents
(used To dissolve Nu -salts )
.am#onfF:aEEEEgmYEEkhEtFm?toaEnFamIf
↳wows for more flexibility during transition state
#'S polar Apnoeic solvents :
eye .Basioity
-mssolve anions without H-bonds
CHARGED ~'t +two #-Causing large RATE INCREASE
1~'tiot →~OH
-trend reflects BASIUTY trends
WNUINNGED ~It Hzo *
~I +:p Cut,}→~NIH
3)3+ I
-
solvent Breakdown :
PROTKSOWENTS pvotiv =Cloaking ,was vealtive at -bonds )
@¥me Nat +Nau ¥'s pit Aprotiu =No coating ,Faster win (Dipole)
3aIt utssutit
#utrecht
;eI
.II¥tff
APROTLC AUDS 0
11
@KYW +Natt Nau ¥4 KY
"
sterns :
•
larger
=Better Leaving Group
=worse Nuueopwile
