MCELLBI 100B Lecture Notes - Lecture 25: Malonyl-Coa, Acyl Carrier Protein, Acetyl-Coa
3 May 2020
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Document Summary
Fatty acid and isprenoid biosynthesis are the modular biological synthetic pathways: pathways can produce many diverse molecules. Acc activity is tightly controlled: acc is the committed step towards biosynthesis, regulators, citrate is an allosteric activator of acc. Is citrate levels are high, do synthesis, positive regulator: palmitoyl-coa is a feedback inhibitor, 16 c fatty acid, product, feedback inhibitor, so when levels are high, enzyme is suppressed, acc exists in two quarternary states, active polymer. The whole cycle: enzyme associated with acetyl coa, primes with malonyl coa, those 2 react, chain, grown by 2 separate carbons, reduce, process can renew. Contrasts with b-oxidation: have to use atp to activate ac-coa, use of the acp instead of coa, uses of nadph instead of fad and nad. Synthesis is driven by spatial segregation of metabolism: mostly in the cytosol in animals, challenge of where intermediates are, some tailoring reactions that can happen, like elongation and desaturation, happen in.
