MCELLBI 104 Lecture 22: Genomics -- Genome-Wide Association Studies (GWAS)
8 Apr 2016
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Slide 8: genotype linked to trait of interest, marker might not be causative but get huge patterns of linkage across markers on the chromosomes, even crude map, can get foot in door and learn something about trait variation. Slide 20: all these genotypic paths, common alleles. Learn something important by that method: genome is bunch of haplotypes, chunks of genetic variation. These two sites are in le, not in ld b/c allele frequencies are the haplotypes are exactly what you expect 25% each. Slide 39: f8-ish cross, after 6 more rounds of recombination, chromosomes look more shuffled, more recombination each generation, shuffle chromosome states. Slide 41-42: selective sweep, footprint of homozygousity, sites farther away, mutations always arising on haploid chromosomes, recognize local neighborhood of chromosome where mutation arose, recombination in population. Show in red or white: red = these 2 are in ld, white = not in ld, recombination, site where you see ld breakdown.
