MCELLBI 104 Lecture Notes - Lecture 32: Statistical Significance, Wild Type, Zygosity
8 Apr 2016
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Show us how genetics, genomics, and cell biology work together: can"t understand genetics and genomes w/o understanding cell biology. 200 points: 100 on cell biology, 1/3 each on disease modules, human disease, footprint that infectious diseases have left in genome. Slide 7: alice in wonderland , quote from that movie, hosts are trying to evade infection, parasites try to evade detection. Slide 9: insect prefers to eat green ones, then soon no more green ones, birds are parasites, green individuals may die off due to their genotype, then you get allele frequencies changing in the population. Slide 10: drop in fitness, drop in frequency, over number of generations. What that leaves is in genome population, a big homozygous stretch. Look at outliers and figure out what"s happening: graph, skin pigmentation, slc24a5 locus, multiple functions including resistance to disease, look at humans from diff populations, see that americans,
