MCELLBI 104 Lecture Notes - Lecture 36: Sh2 Domain, Hydrolysis, Valine
8 Apr 2016
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Slide 3: single allele of a ligand for one of these rtks (called igf1) turns out to be major determinant of size of dogs, difference b/w small and huge dogs is presence of specific allele. Igf1, homozygous in small dogs, nearly absent in large dogs. Egfr signal: determine diagnosis in patient to design therapy that"s targeted for it. P group: create binding site to bring the two together, addition of phosphate can also block binding of another protein, inhibitory phosphate, wee1 in m-cdk. Slide 14: gef causes exchange for active form, hydrolysis stimulated by gap protein, turn signal off. Slide 18: ligand binds to rtk on cell surface activate ras activate raf. P-ate mek p-ate mapk p-ate tf stimulate specific genes required for growth and proliferation: how outside ligand can directly lead to internal cellular event through process of signal transduction, increase rate. Slide 19: be familiar with logic, rtk primary transduction, grb2/sos relay.
