MCELLBI 104 Lecture Notes - Lecture 38: Antimicrobial Peptides, Sequence Motif, Pathogenic Bacteria

• School: Berkeley
• Department: Molecular And Cell Biology
• Course: MCELLBI 104
• Professor: Miller Craig

Document Summary

Is the human version of fly dorsal patterning; used as very first line of defense: synthesized in liver, dumped into blood stream to protect you, saa is such a gene; serum amyloid alpha. Bring immune cell to site of wound/infection: tlr4: toll-related receptor 4. Phosphorylate inhibitory protein called ikb (i kappa b); human cactus protein. Phosphorylation of ikb leads to release of nfkb (human dorsal diff protein) Enters the nucleus and activates saa and other genes needed to promote wound healing and fight off infection. Some are linked to polymorphisms in tlr4. Can"t put off infections that we normally fight off with our liver. If not severe infection, hang in there until immune response kicks in. But usually hyper sensitive to acute infection. Why are humans more sophisticated that flies, worms, fish, frogs: answer is in enhancer, exon, intron, basic structure of gene, exon = basic information of our gene, give rise to diff pieces of our proteins.