NUSCTX 10 Lecture Notes - Lecture 17: Calcifediol, Calcitriol, Osteomalacia
30 Mar 2016
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Body can synthesize from cholesterol and uv light. Conditionally essential: if not enough body synthesis, need from diet. Forms: vd2: plant sources and supplements, vd3: animal sources and body, ** vd2 is less biologically active than vd3, ** vd binding protein required for transport in blood. Factors affecting vd synthesis in body: latitude, season, time of day, skin pigmentation, sunlight, sunscreen. Skin: previtamin + heat vd3 (calciol) liver (calcidiol) kidney (calcitriol) Diet vd2/ vd3 vd3 (calciol) liver (calcidiol) kidney (calcitriol) Rickets (bowed legs, beaded ribs) + osteomalacia. Hypercalcemia- increased ca causes calcification of tissues and kidney stones. Antioxidant that protects cell membranes from free radical oxidation. 8 compounds, sources from plant oils and nuts. Rare, can occur in diseases of fat malabsorption and premature infants. Hemolytic anemia: (not iron) few rbc because membranes rupture from oxidative damage. Need for blood clotting and blood formation. Rare, can occur with fat malabsorption, antibiotics and anticoagulant drugs.
