NUSCTX 110 Lecture Notes - Lecture 3: Respiratory Acidosis, Multiple Drug Resistance, Xenobiotic
28 Sep 2018
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Immediate compensation: low ph drives respiratory response, effect is to reduce pco2 and tends to restore hco3/co2 ratio toward 20/1: long term correction: renal excretion of h+ restoration of hco3, long term correction: renal excretion of excess hco3. Discussion #1: painkillers inhibit cox1 (anti-inflammatory) and cox2 (pain), enzyme associated with pain and inflammation, reduce prostaglandin that signals the body to fix the pain. Want cox1 to be active and cox2 to be inactive. But there are companies that only inhibit cox2 (cox2 selective inhibitors). But found out this lead to severe heart defects, cardiodefective with this drug is that it has a transcription factor (regulates cell transcription activity of cell), which is really bad because it targets multiple genes. When this happens sall4 actually regulating genes decreases growth. Also influenced igf1: hallidomide original purpose is to prevent morning sickness. The problem: dose-reponse dose determines toxicity.
