BIOL 118 Lecture Notes - Lecture 4: Cytosine, Guanine, Nitrogenous Base

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Nucleotide is the building block of nucleic acid. Has a phosphate group, a sugar, and a nitrogenous base. Sugars can be ribose in rna or deoxyribose in dna. Look at the 2nd carbon in the sugar- if its oh then its ribose, if its just h then its deoxyribose(lossed the o= deoxy) Know how to draw a condensation reaction/phosphodiester. Phosphate group (p with 4 o"s-double bond on one o), bonded to a sugar (ch2. + oh/h"s) (phosphate group bonds to c5 and c3), with a nitrogenous base bonded to c1. Sugar phosphate backbone runs from 5" to 3". Anti-parallel (other side of the ladder) runs from 3" to 5". Why is complementary base-pairing not possible if two dna strands are aligned in parallel fashion? (why does it run from 3" to 5" on the anti-parallel instead of 5" to 3" again?)

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