BIOL 311 Lecture Notes - Lecture 18: Trastuzumab, Basal-Cell Carcinoma, Cancer Stem Cell
Document Summary
Replaced heart disease as the #1 killer disease in the world: There has been a decrease in heart disease. Lifespan has increased ~ much of cancer is time-dependent. Increase in smoking in india, china, and asia. Don"t grow in soft agar: usually don"t secrete proteases, larger ~ spend most of their time in. Soft agar: semi-solid medium where cells are clumped at bottom. Genetic defects in cancer cells: >50% have these particular defects, though there are others. Rouse sarcoma virus: discovered by peyton rous in 1911 virus (retrovirus, Locks up the tumor repressor gene so cell can"t commit: virus is formed of a large t antigen: protein in cancer surveillance apoptosis system. Binds to p53 and rb proteins (tumor suppressor genes), removing them from the cell cycle. Hpv: causes cervical cancer or genital warts. First cancer vaccine was developed for this cancer (gardasil) Epstein barr virus: chromosomal translocation virus. Causes hodgkin"s or: radiation (uv light): increases thymine dimers.
