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Lecture 7

Lecture 7 BI315.docx

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CAS BI 315
Eric Widmaier

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Lecture 7 02/17/2014 Neurotransmitter: norepinephrine­small derived from an amino acid; also derived from a pathway that other  neurotransmitters could come from.  Peripheral actions of norepinephrine in flight­or­fight: NT on the peripheral can have different targets and actions (muscle and organs) ▯caused by stress or any  real threat to homeostasis; it can be moderate or severe, the magnitude can change Heart: cardiac, increase function; rate or strength of contraction Beta 1 norepinephrine receptors­increase contractility­strength of contraction. Beta 1 adrenergic receptor  and together it can increase cardiac output which is proportional to blood pressure. Hypertension: high  blood pressure, so you would want to prevent norepinephrine from acting on Beta 1 receptors, so: Block with an antagonist: beta­blockers (first treatment) Smooth muscle: involuntary muscle­tends to surround structures that can expand and collapse­stomach,  bladder, blood vessels.  Blood vessels: Beta2 receptors: results in dilation, vasodilator.  Stomach and kidneys have alpha receptors and norepinephrine binds to alpha receptors and it results in  vasoconstriction, narrowing of blood vessels. Same tissue, same vascular structure, yet the muscle knows it’s going to skeletal muscle with the different  receptors. Skeletal muscle will have beta receptors.  The signals for fight or flight go to the hypothalamus and the cortex.  Pulmonary smooth muscle: Beta2 receptors, results in bronchodilatoin. Beta2 is related to cAMP and to  relaxation.  Asthma and hypertension: use beta­blockers, but with asthma? Asthm
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