CAS BI 525 Lecture Notes - Lecture 30: Enzyme, Insulin, Neprilysin
17 Dec 2016
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Treating hippocampi slices with oligomers decrease ltp. Pla(cid:395)ues a(cid:396)e a featu(cid:396)e of alzhei(cid:373)e(cid:396)"s (cid:271)ut (cid:374)ot (cid:272)lea(cid:396) if the(cid:455) a(cid:396)e to(cid:454)i(cid:272) to (cid:374)eu(cid:396)o(cid:374)s. Glutamergic neuronal death first neurons degenerating. Abeta is a biomarker for the disease: molecule specific to a certain disease and changes with progression of the disease, slide 3 app mutations that lead to increase in abeta. Found either at the beginning of abeta. Animal model: transgene for human app carrying a mutation increase amount of abeta, need to test for symptoms as well as biological. Cored are always abeta 42: tested with thioflavin s amyloid in aggregates, cognitive behavior tests. Morris water maze do they remember where the platform is. 2 phases: training (platform is made visible then covered and try to find, trials. Cognitive latency: number of time it takes to find platform. If has good memory, they will perform better on each trial. Wt animals at 3,6, or 9 mo: does not change.
