CAS BI 107 Lecture 5: Inbreeding Evolutionary Mechanisms

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Example) population has genotype ratio 46aa: 28aa: 26aa and is subject to complete inbreeding. 46 aa 28 aa 26aa (1st generation) heterozygote population splits into half, remaining half is split again between each homozygote population. 28/2 = 14 aa, 46 + 14/2 = 53 aa, 26 + 14/2 = 33 aa. Inbreeding (mating between relatives) increases frequency of homozygotes and decreases frequency of heterozygotes. Does not cause evolution because allele frequencies do not change, only the genotype frequencies. Inbreeding depression: decline in average fitness that takes place when homozygosity increases and heterozygosity decreases in a population. Inbreeding increases frequency of homozygous recessive individuals and thus frequency of individuals with two recessive mutation genes. Evolutionary mechanisms: mutation: production of new alleles, random in terms of fitness. Most mutations lower fitness: random genetic drift: change in genetic variation from generation to generation due to random sampling error.

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