CAS BI 107 Lecture Notes - Lecture 4: Genotype Frequency
18 Sep 2015
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30 women over the age of 50: 4mm, 23mv, 3vv. P^2 + 2pq + q^2 = 0. 27 mm + 0. 50 mv + 0. 23 vv. For the 140 women under the age of 50: 31mm, 72 mv, 37vv. P^2 + 2pq + q^2 = 0. 229 mm + 0. 499 mv + 0. 271 vv. Because the predicted h-w genotype percentages are different from the observed phenotypes in the population, the population is out of equilibrium. In africa, the incidence of the s allele is 0. 12 = q. P^2 = 0. 774 - proportion of aa individuals. Q^2 = 0. 014 - proportion of ss individuals. 2pq = 2(0. 88)(0. 12) = 0. 211 - proportion of as individuals. Only 1 in 375 americans of african descent develop sickle cell anemia (ss individuals). If the population is in h-w equilibrium, then q = square root of 0. 00267 = 0. 052. P = 1. 000 - 0. 052 = 0. 948. 2pq = 0. 099, q^2 = 0. 00267, p^2 = 0. 8989.
