CAS BI 203 Lecture 20: Lecture #20

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Spectrin tetramers interact with actin filaments resulting in a spectrin-actin network form the cortical cytoskeleton that controls cell shape. Other types of cells have similar linking proteins. Dystrophi(cid:374) is a(cid:271)se(cid:374)t or a(cid:271)(cid:374)or(cid:373)al i(cid:374) patie(cid:374)ts (cid:449)ith du(cid:272)he(cid:374)(cid:374)e"s (mild) or be(cid:272)ker"s (severe) muscular dystrophy, respectively. Muscle contraction: actin filaments with myosin, ma molecular motor, to convert atp to mechanical energy, generating force and movement. Key: actin and myosin ii filaments overlap on either side of m line. Sliding filament model of muscle contraction: contraction entails the sliding of actin and myosin filaments past each other. Myosin ii = motor protein that drives filament sliding (dependent on atp: a protein complex with 2 key domains, globular head region bind actin, coil of two alpha-helical tails associates in parallel to form staggered. Hundreds of myosin contract a sarcomere: hundreds-thousands of sarcomeres contract a skeletal muscle.

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