CAS BI 203 Lecture Notes - Lecture 17: Secretion, N-Terminus, Endoplasmic Reticulum
18 Jan 2020
School
Department
Course
Professor
Document Summary
How do cells traffick proteins mrnas exit nucleus via specificprotein complex. A nuclear proteins are imported into nucleus via importins after translation on free ribosomes i proteinsdestined for many compartments are imported following free ribosomes peroxisomes chloroplasts mitochondria translation on. All translation starts on free ribosomes in cytosol ii but proteins destined for several other compartments are trafficked differently via the secretory pathway a for example plasma membrane proteinssecreted proteins er proteinsgolgiproteinslysosomal proteins. B secretory pathway common pathway cer golgi vesicles i key study examined the path through which newly synthesized proteins are secreted from cells from pancreatic cells a method. 1 purse labelled newly synthesized proteins with radioactive hot. 3 tracked location of radioactive proteins through time non radioactive cold a a s results. 1 after 3 min protein associated with er. 3 after 120 min chase all proteins in secretory vesicles radioactive proteins in golgi.
