CAS BI 315 Lecture Notes - Lecture 9: Hematocrit, Red Blood Cell, Fibrinogen
14 Jun 2018
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I. Primer on Core Concepts of CV and Respiratory Physiology
A. Bulk Flow vs Diffusion
1. Bulk - all parts of fliquid/gas are equally subject to orce of movement; all
parts move together
2. Diffusion - each component molecule subject to own chem and elec
gradient
B. Flux prop gradient/resistance
1. Can describe bulk flow of air and blood
2. Can describe diffusion of oxygen, carbon dioxide, orother molecules
3. When apply formula, ask
a) What is gradient (chem, pressure?)
b) What are resistors
4. Ficks law - diffusion rate prop to surface area
5. Branching maximizes SA in volume
II. Cardiovascular
A. Function
1. Transport oxygen, nutrients, hormones, wastes and other chem through
body
III. Blood
A. Liquid - plasma (3L)
1. Watery, viscous
2. Plasma proteins - albumin, globulins, fibrinogen (dont need to know)
a) Play osmotic regulation role
3. Solutes - nutrient and waste molecules, na+, k+, cl-, and other ions
4. Dissolved gases - oxygen and co2
B. Leukocytes and platelets
C. Solids -
D. Erythrocytes - 45%; 2.5 L
E. Isolate components from centrifugation
F. Percentage of whole blood that is made up of packed erythrocytes is called
hematocrit
G. Oxygen for na/k pump in neurons and contraction in muscle cells
1. Hematocrit detects anemia - Low RBC - fatigue, slow cognitive, cramping,
lethargic
IV. Gradients -
A. Indiv components move down gradient
B. Bulk flow of blood by pressure gradient - high to low
C. Heart establishes pressure gradient
V. Resistance in CV - friction that impedes flow
A. Smaller vessel has more resistance
B. Decrease resistance by stretchiness
VI. Pressure, flow, and resistance
A. F=detaP/R
B. Flow rate directly proportional to pressure diff btw 2 pts
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