CAS BI 525 Lecture Notes - Lecture 32: Aldehyde, Signal Transduction, Notch Signaling Pathway
17 Dec 2016
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Document Summary
Gamma secretase: cleaves c99 into abeta, function is extremely important, could be toxic through gain of toxic function and loss of physiological function, physiological function: Gamma-secretase complex and the phenomenon of intramembrane proteolysis. However, ps1 is necessary for viability: spans membrane 8 times, aspartyl residues located at intracellular domains; cytosolic loop between two aspartyl residues. If you knockout any of these you have the same phenotype as. Nicastrin: curical for the identification of the substrate. C99/c83 would be recruited by nicastrin and be placed between the aspartyl residues where it can be cleaved. Mutations on presenillins (how connected to gamma secretase) are more likely to produce abeta 42: abeta 42/abeta 40, abeta 42 more toxic. Some of the mutations on ps1 change the abeta 42/abeta 40 (gain of toxic fx) Some of the mutations on ps1 change the function of ps (loss of physiological.
