CAS CH 203 Lecture Notes - Lecture 2: Mit Opencourseware, Protein Folding, Structural Motif

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2 Dec 2017
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Polymer formation from amino acid building blocks requires a dehydration reaction. [note: all polymerization reactions important in biology involve dehydration reactions. ] The ribosome is the macromolecular machine inside cells that performs the same reaction. They catalyze this dehydration reaction without activation of the ho group for leaving. Note by convention, polypeptides are normally written with the n terminus on the left and the c terminus on the right. 1: hierarchy in protein structure with hemoglobin (hb) as an example, primary structure: the amino acid sequence of the polypeptide chain (figure 1a). Anfinsen won the nobel prize for the formulation of anfinsen"s hypothesis that the primary sequence is sufficient to determine the three dimensional structure of a protein. Groel-groes in e. coli with similar counterparts in eukaryotic systems). You will learn about this machinery in chemistry 5. 08. Protein folding is particularly challenging given the crowded environment of the cell (lecture 1) and hydrophobic stretches of amino acids.

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