CAS PH 251 Lecture Notes - Lecture 8: Nazi Human Experimentation, Evidence-Based Medicine, Nuremberg

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Therapy: biomedical interventions designed only to help an individual or group of individuals. Research: studies or interventions intended to lead to generalizable scientific knowledge. Clinical type: the subjects of the study suffer from some illness or susceptibility that the experiment of the study aims to treat. (therapeutic component) Non clinical type: subjects of experiment do not directly benefit from the experiment. Clinical research like hiv drug trials see the subjects benefit from the experiment. Incomplete model: we know how bodies react to certain chemicals, but new stuff can"t be known without actual testing. Culture of cells: isolated tissue cultures will not allow you to understand the complexity of the way the culture interacts with the whole body. E. g. tissues out in the body could just shut down the. Experiment on non-human animals: human share many genetic components with other species but you cannot be a 100% certain that the drugs will react the same way.

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