BIOL 0280 Lecture Notes - Lecture 13: Beta Oxidation, Thiolysis, Lipid
7 Nov 2016
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Document Summary
Hydrolysis of glycerolipids by lipase releases fatty acids for catabolism. Necessary because the configuration at c2 needs to be inverted to convert to d-glyceraldehyde 3p. Otherwise, direct oxidation at c1 of l-glycerol 3-p would not be productive. Bind fatty acid to co-a (in cytosol) = very high e expense. Net: atp + fa + coa --> fatty acyl-coa + amp + 2 pi. Fatty acids transported into mitochondria as acylcarnitine for oxidation. Formation of acyl carnitine is the rate-limiting step in fatty acid oxidation. Carnitine-mediated transport releases co-a --> reinstall co-a in matrix to reactivate. Cleavage happens at beta position at the chain. 1st oxidation: oxidize a-b bond with acyl-coa dehydrogenase. The fadh2 that is produced can transfer e- to the. Hydration: enoyl-coa hydratase leads to -oh addition to c. Summary: one round of beta oxidation makes 8 acetyl-coa + 7. Summary: 8 acetyl-coa --> 16 co2 + 8 fadh2 + 24 nadh + 8 atp.
