BIOL 1260 Lecture 17: Epilepsy
2 Dec 2016
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Document Summary
4th most common neurological disorder in us (after migraine, Prevalence greater than autism spectrum + cerebral palsy + Seizure: clinical manifestation of an abnormal and excessive excitation and synchronization of a population of cortical neurons: singe seizure != epilepsy, a healthy brain can have a seizure, acute changes in availability of neurotransmitters, ex. Phases of a seizure: preictal (prior to) Aura, similar to migraine visual, auditory, olfactory, tatile: ictal (during) Symptoms depend on type of seizure: postictal (after, interictal (period between seizures) Classification of seizures subclinical seizures: partial seizure: activity confined to one region of cortex focal, jacksonian, secondary generalized seizure: activity begins in a focus but spreads to subcortical area. Tle, tonic-clonic: primary generalized seizure: abnormal synchronization between thalamic and cortical cells. Can be asymmetrical and may not include entire cortex: focal (partial) seizure. Seizure activity starts in a localized region of the brain.
