NUTR-4550 Lecture Notes - Lecture 14: Proopiomelanocortin, Melanocortin 4 Receptor, Amylin
Document Summary
Nutr 4550: bioenergetics- control of energy balance (test 2, lecture 6) Gut hormones: (gut refers to the intestine: pyy glp-1, glp-2, cck (small intestine), and oxm all increase in response to food intake. Ghrelin(stomach) decreases in response to a meal. Pancreatic hormones: pancreatic peptide (released by pp cells), amylin, and insulin (both released by beta cells) all will increase with food intake. Glucagon will decrease as a result (alpha cells) Adipose tissue hormone-leptin(from adipocytes: increases with food intake, especially when global energy stores within the body are increasing. Energy surplus: over-consuming: leptin and insulin will both increase within the body. Arc of hypothalamus: leptin and insulin will decrease the npy and agrp (agouty protein) pathway, leptin and insulin will interact with pomc neurons to increase a-msh binding to the anorexogenic neuropeptide through mc4r. By interacting with the pomc neurons at a-msh, the receptor is being utilized and the agrp protein can no longer bind the the neuropeptide.
