NUTR-4550 Lecture Notes - Lecture 20: Choline Kinase, Methylcobalamin, Betaine
Document Summary
Vitamin b12, and vitamin b6 (test 3, lecture 2) Riboflavin will first transform into flavin mononucleotide, to eventually become flavin adenine dinucleotide (fad) A. enzymatic reaction: utilizes fad, lipoic acid, and thdp as coenzymes for pyruvate conversion into. There are 3 proteins involved in this process: pyruvate dehydrogenase, dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase. E1-first enzymatic reaction: pyruvate enters the pyruvate dehydrogenase complex. Thdp (thiamine diphosphate) acts as a carrier for pyruvate. E2: elongation (sort of: lipoic acid and thdp-carbon molecule create a longer intermediate. This intermediate will combine with coenzyme a to form acetyl-coa. E3: captures energy: the reduced lipoic acid has energy that can be captured. Fad (oxidized) will take the two protons from the reduced lipoic acid to form. Fadh and lipoic acid: these donated electrons and protons will be accepted by nad. Nad is the ultimate acceptor for pyruvate dehydrogenase complex.
