Fluid distribution, blood volume regulation, renin-angiotensin-aldosterone system, standing

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Biomedical Science
BMS 360
Douglas Ishii

5 MarchLecture ObjectivesStudy GuideUnderstand how blood volume is regulated and how changes in blood volume and extracellular fluid distribution influence cardiac output and blood pressureUnderstand what the term pressure natriuresis meansUnderstand the difference between volume sensing by stretch receptors and atrial cardiomyocytes and how these mechanisms influence blood volume and pressureBe able to explain and diagram how the reninangiotensinaldosterone system regulates blood pressureUnderstand the central importance of the kidney in blood pressure regulationFluid DistributionTotal body water volume40 L 60 body weightIntracellular fluid volume25 L 40 body weightExtracellular fluid volume15 L 20 body weightInterstitial fluid volume12 L 80 of ECFPlasma volume3 L 20 of ECFBlood Volume RegulationAn increase in blood volume increases central venous pressure right atrial pressure and right ventricular enddiastolic pressure and volumeBlood volume is regulated by the kidneys by adjusting the excretion of water and sodium into the urineIncreased blood volume increases arterial pressure renal perfusion and glomerular filtration rateThis leads to an increase in renal excretion of water and NaPressure natriuresisReflex Regulation
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