BMS 420 Lecture Notes - Propranolol, Cyclic Adenosine Monophosphate, Stroke Volume

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3 Apr 2014
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When cardiac output, and thus venous return, is zero, rap equals mean systemic filling pressure (msfp) If shifted to the left, cardiac performance is enhanced. If shifted to the right, cardiac performance is worse. Vascular tone causes curve to shift to right with dilation, to left with constriction (swivels on mean systemic filling pressure) Enhanced blood volume shifts vascular curve to right, parallel to normal curve. Lower blood volume shifts curve to left, parallel to normal curve. Mean systolic filling pressure shifts along axis here. Regulation of arterial blood pressure and cardiac output. Co = hr x sv = hr x (edv esv) Heart rate: control is dominated by autonomic nervous system but there are other inputs. (we previously have discussed regulation of stroke volume) Sympathetic and parasympathetic nervous systems operate by reciprocal innervation; parasympathetic nervous system dominates via evidence. Block both systems simultaneously: hr which is intrinsic heart rate .

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