Lymphatics, interstitial edema, cardiac electrophysiology

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Biomedical Science
BMS 420
Charles Miller

14 September NFP = (P + C ) –ifP + πif P Starling’s law of filtration (and reabsorption) (P C π ) iffiltration forces (P ifπ )P– absorption forces π P plasma oncotic pressure Arterioles dilate → P iCcreases → more filtration Venules dilate → P incCeases → more filtration Arterioles constrict → more absorption Lymphatics Lymphatics return 3 – 4 L of fluid and 100 – 200 grams of protein to blood stream per 24 hours Importance of integrity of lymphatics? – maintenance of normal osmotic pressure gradient Terminal lymphatic capillaries have no smooth muscle Anchoring filaments pull open the lymphatic vessels One-way valves (open due to pressure differences) Composition: identical to interstitial fluid Drainage: Thoracic duct (lower) and right lymph duct (upper) → venous system (internal jugular/subclavian veins) Lymph flow affected by Interstitial pressure Expansion of interstitial compartment pulls apart anchoring filaments Stretch induced contractions of lymphatic smooth muscle External compression ↑ interstiti
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