Cardiac dynamics, Frank-Starling law, afterload, contractility, factors affecting CO

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Colorado State University
Biomedical Science
BMS 420
Charles Miller

28 September Cardiac dynamics P-V loops Inotropy Length-tension concept Matching of venous return/cardiac output BP/CO regulation Cardiac Dynamics Pressure-volume loops (plot of ventricular blood pressure vs. ventricular blood volume) Ejection fraction = SV/EDV Measure of contractility Factors Affecting Performance (CO or SV) Heart rate Preload Afterload Contractility Frank-Starling Law Preload: Within limits, the greater the stretch on the heart muscle (blood volume) the greater is the stroke volume. Stretched fibers generate more force. RV CO = LVCO CHF (congestive heart failure) – poor contractility, lower cardiac output → increased blood volume, increased EDV, increased performance (almost returned to normal) Heart attack – stroke volume for same end-diastolic volume decreases, after time preload increases due to fluid retention, so stroke volume increases again Mechanism of F-S Curve Optimal sarcomere length = 2.4 μ Decreasing lengths develop less tension due to
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