BMS 420 Lecture Notes - Arteriole, Stroke Volume, Ejection Fraction

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4 Apr 2014
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Pressure-volume loops (plot of ventricular blood pressure vs. ventricular blood volume) Preload: within limits, the greater the stretch on the heart muscle (blood volume) the greater is the stroke volume. Chf (congestive heart failure) poor contractility, lower cardiac output increased blood volume, increased edv, increased performance (almost returned to normal) Heart attack stroke volume for same end-diastolic volume decreases, after time preload increases due to fluid retention, so stroke volume increases again. Reduced ca++ affinity of tnc which reduces ca++ sensitivity to myofilaments. Reduced ca++ entry into cell and hence less ca++ induced ca++ release. The force opposing myocardial contraction (the weight hanging on a muscle). The aortic blood pressure is an indicator of the afterload. High afterload for long time period thick heart walls. Afterload reducing agents would decrease tone of arterioles. The force generated by the heart under conditions of fixed preload and afterload. If contractility (eg epinephrine), stroke volume , end systolic volume .

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