BMS 450 Lecture Notes - Angiotensin Receptor, Ace Inhibitor, Autonomic Nervous System

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14 Jul 2014
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Sympathetic: overall contraction increases arterial resistance (tpr) and venous return. Primary mechanism by which the autonomic nervous system maintains blood pressure. Initiated by stretch (baro) receptors in the carotid artery and the aortic arch. Increased blood pressure baroreceptor increased parasympathetic activity/decreased sympathetic activity decreased cardiac output/decreased peripheral resistance decreased blood pressure. Sympathetic activity promotes release of renin from granular cells in the juxtaglomerular apparatus in the kidney. Decrease in renal perfusion renin acts on angiotensinogen angiotensin i angiotensin ii via ace vasoconstriction, aldosterone/adh ( increased blood volume) ~1 in 5 adults is hypertensive (50 million people) in the us. ~30% of hypertensive adults are unaware of their condition. Most prominent risk factor contributing to cardiovascular disease. For every 20 mm hg increase in systolic blood pressure or 10 mm hg increase in diastolic blood pressure, the risk of death from ischemic heart disease and stroke doubles.

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