LIFE 210 Lecture Notes - Relative Permittivity, Kinetic Theory Of Gases, Conjugate Acid
Document Summary
Collision between molecules energies of ~ 1 kcal mole. Noncovalent bonds require 1 to 5 kcal mole to break kcal mole to break. Van der waals, hydrogen, and ionic are electrostatic interactions. No room for h2o molecules, so not affected by water. Molecule that starts with h attached is donor (weak acid) Has directionality (strongest w/ molecules line up @ 180 ) Dh2o = 80 (because it likes to interact w/ ions) Number of multiple weak non-covalent bonds and interactions. Association rate = a = ka [a] [b] At equilibrium: a = d k [a] [b] = kd [ab] [ a ][ b] ka / kd = Range: 1012 per m to 103 per m. Range: -19 kcal mole to -4 kcal mole. Caused by translocation between chromosomes 9 and 22. Kinases have similar structures with clefts for binding. Blocks activation loop so atp can"t bind to abl.
