ACCT 210 Lecture Notes - Lecture 21: Transplant Rejection, Endosome, Endocytosis
12 Jul 2020
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Learning outcomes: structure of mhc class one and mhc 2 class proteins, how mhc polymorphisms and polygeny ensure efficient presentation, how mhc class one presents peptides from cytosolic proteins, how mhc class 2 presents peptides from exogenous proteins. Importance of cross-presentation in activation of cd8 t cells. Nts: written here as one and two but on presentation as roman numerals (i and ii) Tcrs cannot bind antigens directly like b cells, instead they only bind mhc bound antigens. Mhc class one is responsible for identifying cells infected with intracellular pathogen. Mhc class 2 is responsible for cells responding to extracellular pathogen. Mhc class one presents peptides derived from cytosolic proteins to cd8 tc cells e. g. antigens from viruses. Class two presents peptides derived from proteins in intracellular vesicles to cd4h cells e. g. antigens from extracellular pathogens. Tcr interacts simultaneously with both mhc associated peptides (compound ligand) meaning tcr recognises peptide in context of mhc.
